Original articles


Since 2012

  1. Park J, Kwon M, Kim KH, Kim TS, Hong SH, Kim CG, Kang SG, Moon JH, Kim EH, Park SH, Chang JH, Shin EC. Immune checkpoint inhibitor-induced reinvigoration of tumor-infiltrating CD8+ T cells is determined by their differentiation status in glioblastoma. Clin Cancer Res 2019 Epub ahead of print
  2. Kim KH, Cho J, Ku BM, Koh J, Sun JM, Lee SH, Ahn JS, Cheon J, Min YJ, Park SH, Park K, Ahn MJ, Shin EC. The first-week proliferative response of peripheral blood PD-1+CD8+ T cells predicts the response to anti-PD-1 therapy in solid tumors. Clin Cancer Res 2019 Epub ahead of print
  3. Lee YH, Kim SR, Han DH, Yu HT, Han YD, Kim JH, Kim SH, Lee CJ, Min BH, Kim DH, Kim KH, Cho JW, Lee WW, Shin EC, Park S. Senescent T cells predict the development of hyperglycemia in humans. Diabetes 2019 Epub ahead of print
  4. Kwon M, Choi YJ, Sa M, Park SH, Shin EC. Two-round mixed lymphocyte reaction for evaluation of the functional activities of anti-PD-1 and immunomodulators. Immune Netw 18:e45, 2018
  5. Kim AR, Park J, Kim JH, Kwak JE, Cho Y, Lee H, Jeong M, Park SH, Shin EC. Herpes zoster DNA vaccines with IL-7 and IL-33 molecular adjuvants elicit protective T cell immunity. Immune Netw 18:e38, 2018
  6. Park J, Kim CG, Shim JK, Kim JH, Lee H, Lee JE, Kim MH, Haam K, Jung I, Park SH, Chang JH, Shin EC, Kang SG. Effect of combined anti-PD-1 and temozolomide therapy in glioblastoma. Oncoimmunology 8:e1525243, 2018
  7. Ryu DH, Yu HT, Kim SA, Lee YM, Hong SH, Yoon YR, Kim DJ, Kim HC, Moon HB, Shin EC, Lee DH. Is chronic exposure to low-dose organochlorine pesticides a new risk factor of T-cell immunosenescence? Cancer Epidemiol Biomarkers Prev 27:1159-1167, 2018
  8. Min B, Choi H, Her JH, Jung MY, Kim HJ, Jung MY, Lee EK, Cho SY, Hwang YK, Shin EC. Optimization of large-scale expansion and cryopreservation of human natural killer cells for anti-tumor therapy. Immune Netw 18:e31, 2018
  9. Kim MH, Kim CG, Kim SK, Shin SJ, Choe EA, Park SH, Shin EC, Kim J. YAP-induced PD-L1 expression drives immune evasion in BRAFi-resistant melanoma. Cancer Immunol Res 6:255-266, 2018
  10. Youn JC, Kim JY, Jung MK, Yu HT, Park SH, Kim IC, Lee SK, Choi SW, Han S, Ryu KH, Park S, Shin EC. Analysis of cytomegalovirus-specific T-cell responses in patients with hypertension: comparison of assay methods and antigens. Clin Hypertens 24:5, 2018
  11. Choi YS, Jung MK, Lee J, Choi SJ, Choi SH, Lee HW, Lee JJ, Kim HJ, Ahn SH, Lee DH, Kim W, Park SH, Huh JR, Kim HP, Park JY, Shin EC. Tumor necrosis factor-producing regulatory T cells are associated with severe liver injury in patients with acute hepatitis A. Gastroenterology 154:1047-1060, 2018
  12. Kim J, Chang DY, Lee HW, Lee H, Kim JH, Sung PS, Kim KH, Hong SH, Kang W, Lee J, Shin SY, Yu HT, You S, Choi YS, Oh I, Lee DH, Lee DH, Jung MK, Suh KS, Hwang S, Kim W, Park SH, Kim HJ, Shin EC. Innate-like cytotoxic function of bystander activated CD8+ T cells is associated with liver injury in acute hepatitis A. Immunity 48:161-173, 2018
  13. Choi YJ, Kim SB, Kim JH, Park SH, Park MS, Kim JM, Han SH, Shin EC. Impaired polyfunctionality of CD8+ T cells in severe sepsis patients with human cytomegalovirus reactivation. Exp Mol Med 49:e382, 2017
  14. Yu HT, Youn JC, Kim JH, Seong YJ, Park SH, Kim HC, Lee WW, Park S, Shin EC. Arterial stiffness is associated with cytomegalovirus-specific senescent CD8+ T cells. J Am Heart Assoc 6:e006535, 2017
  15. Sung PS, Hong SH, Lee J, Park SH, Yoon SK, Chung WJ, Shin EC. CXCL10 is produced in hepatitis A virus-infected cells in an IRF3-dependent but IFN-independent manner. Sci Rep 7:6387, 2017
  16. Sung PS, Hong SH, Chung JH, Kim S, Park SH, Kim HM, Yoon SK, Shin EC. IFN-l4 potently blocks IFN-a signalling by ISG15 and USP18 in hepatitis C virus infection. Sci Rep 7:3821, 2017
  17. Kang S, Ahn S, Lee J, Kim JY, Choi M, Gujrati V, Kim H, Kim J, Shin EC, Jon S. Effects of gold nanoparticle-based vaccine size on lymph node delivery and cytotoxic T-lymphocyte responses. J Control Release 256:56-67, 2017
  18. Oh IS, Textoris-Taube K, Sung PS, Kang W, Gorny X, Kähne T, Hong SH, Choi YJ, Cammann C, Naumann M, Kim JH, Park SH, Yoo OJ, Kloetzel PM, Seifert U, Shin EC. Immunoproteasome induction is suppressed in hepatitis C virus-infected cells in a protein kinase R-dependent manner. Exp Mol Med 48:e270, 2016
  19. Kim B, Choi YJ, Seo H, Shin EC, Choi S. Deterministic migration-based separation of white blood cells. Small 12:5159-5168, 2016
  20. Kim HW, Park IH, You S, Yu HT, Oh IS, Sung PS, Shin EC, Kim KH. Immunogenicity of MenACWY-CRM in Korean military recruits: influence of tetanus-diphtheria toxoid vaccination on the vaccine response to MenACWY-CRM. Yonsei Med J 57:1511-1516, 2016
  21. Kim JH, Choi YJ, Lee BH, Song MY, Ban CY, Kim J, Park J, Kim SE, Kim TG, Park SH, Kim HP, Sung YC, Kim SC, Shin EC. Programmed cell death-ligand 1 alleviates psoriatic inflammation by suppressing IL-17A production from PD-1hi T cells. J Allergy Clin Immunol 137:1466-1476, 2016
  22. Shin SY, Jeong SH, Sung PS, Lee J, Kim HJ, Lee HW, Shin EC. Comparative analysis of liver injury-associated cytokines in acute hepatitis A and B. Yonsei Med J 57:652-657, 2016
  23. Lee J, Chang DY, Kim SW, Choi YS, Jeon SY, Racanelli V, Kim DW, Shin EC. Age-related differences in human palatine tonsillar B cell subsets and immunoglobulin isotypes. Clin Exp Med 16:81-87, 2016
  24. Chang S, Sung PS, Lee J, Park J, Shin EC, Choi C. Prolonged silencing of diacylglycerol acyltransferase-1 induces a dedifferentiated phenotype in human liver cells. J Cell Mol Med 20:38-47, 2016
  25. Sung PS, Cheon HJ, Cho CH, Hong SH, Park DY, Seo HI, Park SH, Yoon SK, Stark GR, Shin EC. Roles of unphosphorylated-ISGF3 in HCV infection and interferon responsiveness. Proc Natl Acad Sci USA 112:10443-10448, 2015
  26. Seong YJ, Sung PS, Jang YS, Choi YJ, Park BC, Park SH, Park YW, Shin EC. Activation of human natural killer cells by the soluble form of cellular prion protein. Biochem Biophys Res Commun 464:512-518, 2015
  27. Choi YS, Lee J, Lee HW, Chang DY, Sung PS, Jung MK, Park JY, Kim JK, Lee JI, Park H, Cheong JY, Suh KS, Kim HJ, Lee JS, Kim KA, Shin EC. Liver injury in acute hepatitis A is associated with decreased frequency of regulatory T cells caused by Fas-mediated apoptosis. Gut 64:1303-1313, 2015
  28. Yu HT, Youn JC, Lee J, Park S, Chi HS, Lee J, Choi C, Park S, Choi D, Ha JW, Shin EC. Characterization of CD8+CD57+ T cells in patients with acute myocardial infarction. Cell Mol Immunol 12:466-473, 2015
  29. Choi YS, Lee DH, Shin EC. Relationship between poor immunogenicity of HLA-A2-restricted peptide epitopes and paucity of naïve CD8+ T-cell precursors in HLA-A2-transgenic mice. Immune Netw 14:219-225, 2014
  30. Chang DY, Song SH, You S, Lee J, Kim J, Racanelli V, Son H, Shin EC. Programmed death-1 (PD-1)-dependent functional impairment of CD4+ T cells in recurrent genital papilloma. Clin Exp Med 14:305-313, 2014
  31. Nam SJ, Oh IS, Yoon YH, Kwon BI, Kang W, Kim HJ, Nahm SH, Choi YH, Lee SH, Racanelli V, Shin EC. Apocynin regulates cytokine production of CD8+ T cells. Clin Exp Med 14:261-268, 2014
  32. Sung PS, Murayama A, Kang W, Kim MS, Yoon SK, Fukasawa M, Kondoh M, Kim JS, Kim H, Kato T, Shin EC. Hepatitis C virus entry is impaired by claudin-1 downregulation in diacylglycerol acyltransferase-1-deficient cells. J Virol 88:9233-9244, 2014
  33. Lee J, Kim J, Lee J, Shin SJ, Shin EC. DNA immunization of Mycobacterium tuberculosis resuscitation-promoting factor B elicits polyfunctional CD8+ T cell responses. Clin Exp Vaccine Res 3:235-243, 2014
  34. Youn JC, Yu HT, Jeon JW, Lee HS, Jang Y, Park YW, Park YB, Shin EC, Ha JW. Soluble CD93 levels in patients with acute myocardial infarction and its implication on clinical outcome. Plos One 9:e96538, 2014
  35. Kang W, Sung PS, Park SH, Yoon S, Chang DY, Kim S, Han KH, Kim JK, Rehermann B, Chwae YJ, Shin EC. Hepatitis C virus attenuates interferon-induced MHC class I expression and decreases CD8+ T cell effector functions. Gastroenterology 146:1351-1360, 2014
  36. Jang YS, Kang W, Chang DY, Sung PS, Park BC, Yoo SH, Park YW, Shin EC. CD27 engagement by a soluble CD70 protein enhances non-cytolytic antiviral activity of CD56bright natural killer cells by IFN-g Clin Immunol 149:379-387, 2013
  37. You S, Cho YH, Byun JS, Shin EC. Melanocyte-specific CD8+ T cells are associated with epidermal depigmentation in a novel mouse model of vitiligo. Clin Exp Immunol 174:38-44, 2013
  38. You S, Choi YS, Hong S, Shin EC. Priming of autoreactive CD8+ T cells is inhibited by immunogenic peptides which are competitive for major histocompatibility complex class I binding. Immune Netw 13:86-93, 2013
  39. Hong S, Lee HW, Chang DY, You S, Kim J, Park JY, Ahn SH, Yong D, Han KH, Yoo OJ, Shin EC. Antibody-secreting cells with a phenotype of Ki-67low, CD138high, CD31high, and CD38high secrete nonspecific IgM during primary hepatitis A virus infection. J Immunol 191:127-134, 2013
  40. Youn JC, Yu HT, Lim BJ, Koh MJ, Lee J, Chang DY, Choi YS, Lee SH, Kang SM, Jang Y, Yoo OJ, Shin EC, Park S. Immunosenescent CD8+ T cells and C-X-C chemokine receptor type 3 chemokines are increased in human hypertension. Hypertension 62:126-133, 2013
  41. Choi YS, Lee JE, Nam SJ, Park JT, Kim HS, Choi KH, Kim BS, Shin EC. Two distinct functional patterns of hepatitis C virus (HCV)-specific T cell responses in seronegative, aviremic patients. Plos One 8:e62319, 2013
  42. Lee J, Choi YS, Shin EC. Ribavirin does not impair the suppressive activity of Foxp3+CD4+ CD25+ regulatory T cells. Immune Netw 13:25-29, 2013
  43. Lim O, Lee Y, Chung H, Her JH, Kang SM, Jung MY, Min B, Shin H, Kim TM, Heo DS, Hwang YK, Shin EC. GMP-compliant, large-scale expanded allogeneic natural Killer cells have potent cytolytic activity against cancer cells in vitro and in vivo. Plos One 8:e53611, 2013
  44. Kang W, Shin EC. Colorimetric focus-forming assay with automated focus counting by image analysis for quantification of infectious hepatitis C virions. Plos One 7:e43960, 2012
  45. Park J, Kang W, Ryu SW, Kim WI, Chang DY, Lee DH, Park DY, Choi YH, Choi K, Shin EC, Choi C. Hepatitis C virus infection enhances tumor necrosis factor-a-induced cell death via suppression of nuclear factor-k Hepatology 56:831-840, 2012